Researchers Combine OCT and 3D Microscopy to Image Embryos
August 28, 2019
Photonics media has featured BOL’s recent multimodal research for mouse embyronic imaging.
Dr. Larin is among the Top 2 percent of most cited researchers in the world
January 9, 2022
According to an updated report from researchers at Stanford University, 46 past and present professors affiliated with the Cullen College of Engineering, including Biomedical Optics Laboratory director Dr. Kirill Larin, are among the Top 2 percent of cited research papers in the world.
August 21, 2022
The Biomedical Optics Lab’s invited tutorial on Optical Coherence Elastography was one of the most downloaded publications in Optica’s Journal of the Optical Society of America A.
August 20, 2022
Congratulations to Md. Mobarak Karin who was awarded the the Zuegel Family Scholarship.
The lab has been issued a patent for its research in ocular pulse-based OCE for corneal biomechanical characterization
August 9, 2022
System and method to measure tissue biomechanical properties without external excitation
Patent abstract: A system and method for measuring biomechanical properties of tissues without external excitation are capable of measuring and quantifying these parameters of tissues in situ and in vivo. The system and method preferably utilize a phase-sensitive optical coherence tomography (OCT) system for measuring the displacement caused by the intrinsic heartbeat. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. Preferably, the method is used to detect tissue stiffness and to evaluate its stiffness due to intrinsic pulsatile motion from the heartbeat. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases and evaluating the efficacy of therapies.
The lab has been issued a patent for its research in ocular pulse-based OCE for corneal biomechanical characterization
August 9, 2022
Patent abstract: An excitation force (internal or external) and phase-sensitive optical coherence elastography (OCE) system, used in conjunction with a data analyzing algorithm, is capable of measuring and quantifying biomechanical parameters of tissues in situ and in vivo. The method was approbated and demonstrated on an example of the system that combines a pulsed ultrasound system capable of producing an acoustic radiation force on the crystalline lens surface and a phase-sensitive optical coherence tomography (OCT) system for measuring the lens displacement caused by the acoustic radiation force. The method allows noninvasive and nondestructive quantification of tissue mechanical properties. The noninvasive measurement method also utilizes phase-stabilized swept source optical coherence elastography (PhS-SSOCE) to distinguish between tissue stiffness, such as that attributable to disease, and effects on measured stiffness that result from external factors, such as pressure applied to the tissue. Preferably, the method is used to detect tissue stiffness and to evaluate the presence of its stiffness even if it is affected by other factors such as intraocular pressure (TOP) in the case of cornea, sclera, or the lens. This noninvasive method can evaluate the biomechanical properties of the tissues in vivo for detecting the onset and progression of degenerative or other diseases (such as keratoconus).
Congratulations to Dr. Achuth Nair
May 19, 2022
Congratulations to Dr. Achuth Nair for securing the National Library of Medicine/Gulf Coast Consortia training program in biomedical informatics and data science fellowship.
Congratulations to Yogeshwari Ambekar for winning the best poster award at LALS2022 conference
April 15, 2022
Yogeshwari Ambekar presented her poster “Multimodal optical imaging combining Optical Coherence Tomography and Brillouin Microscopy to study murine Neural Tube” at the LALS 2022 Coference and was awarded the best poster prize.
Dr. Manmohan Singh’s publication was selected for the cover of the latest issue of Photonics
January 26, 2022
Dr. Manmohan Singh’s research paper “Compressional Optical Coherence Elastography of the Cornea” was selected as the cover for Photonics.
The lab has been issued a patent for its research in ultra-fast OCT and OCE for measuring corneal biomechanical properties
Jan 17, 2023
System and method for measuring intraocular pressure and ocular tissue biomechanical properties
Patent abstract: Provided herein are systems and methods to measure the intraocular pressure, ocular tissue geometry and the biomechanical properties of an ocular tissue, such as an eye-globe or cornea, in one instrument. The system is an optical coherence tomography subsystem and an applanation tonometer subsystem housed as one instrument and interfaced with a computer for at least data processing and image display. The system utilizes an air-puff and a focused micro air-pulse to induce deformation and applanation and displacement in the ocular tissue. Pressure profiles of the air puff with applanation times are utilized to measure intraocular pressure. Temporal profiles of displacement and/or spatio-temporal profiles of a displacement-generated elastic wave are analyzed to calculate biomechanical properties.