Nondestructive depth-resolved imaging of molecular diffusion in tissues can assist in development of novel therapeutic agents and drug delivery systems as well as provide a novel tool for early diagnosis of various epithelial disorders.
The ability to detect sensor signals from below tissue surfaces without the need to implant large capacity power sources, without the need for potentially toxic fluorophores, or without the need for a permanent skin puncture will allow for the development of low-cost, implantable in-vitro monitoring technology that is of profound importance to proper treatment of common diseases, such as diabetes. We have recently developed a micro-retroreflector-based, self–calibrated technology as a platform for a biosensor (Fig 1).
Noninvasive imaging, monitoring and quantification of microbubbles forming in blood and tissues upon rapid changes in barometric pressure are extremely important for effective therapy and diagnostics of several diseases as well as for a number of imaging and drug delivery projects. We are developing the Phase-Sensitive Swept Source OCT (PhS-SSOCT) technique for real-time, sensitive, accurate, and noninvasive imaging and assessment of microbubbles in blood and skin.